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Bio-revitalisation is a broad term that refers to a variety of skin treatments based on the use of natural, biologically active ingredients in advanced skin care and medical aesthetics. In our practice we have mastered an INNOVATIVE, HIGHLY EFFICIENT, NON-INVASIVE, and SAFE method for bio-revitalisation. Using our method, the rejuvenating treatment cocktail with bio-active ingredients (Biostimulators) is directly delivered to the deep layers of the skin without any injections and via a NEEDLE - FREE Electroporation. Skin treatment with Biostimulators applied by means of Electroporation is a non-invasive and painless alternative to the needle-based techniques such as, for example, Mesotherapy, hence it is often referred to as a Virtual or a Needle-free Mesotherapy as well. 

Electroporation is a technique in which an electrical field (momentary electrical pulse) is applied to the skin to create temporary lipid bilateral aqueous channels to boost the permeability of the cell and tissue membranes and thus enable active ingredients to penetrate the skin. Electroporation was developed in the early nineties by scientists from Harvard University and the Massachusetts Institute of Technology (MIT) in the USA to be applied to human skin for transcutaneous drug delivery. This method has been successfully used in clinical medicine and science for a few decades prior to its novel application in Medical Aesthetics field. Electroporation makes use of electric pulses, which opens thin channels in the epidermis through intercellular and intracellular spaces and temporarily alters the plasma membranes allowing bioactive molecules to move inside the skin cells (Figure 1).


Since relatively large molecules can pass through the membrane, electroporation techniques have been used for gene therapy and other transdermal drug therapies very successfully. This technique has evolved over the years and has now been used widely in dermatological and aesthetic treatments. By applying Electroporation pulses to the skin, it increases the penetration efficiency of the active ingredients painlessly and allows any added macromolecules to penetrate to the depth of 0.8-1.1 mm into the dermis. 

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Figure 1: The creation of temporary aqueous microchannels in the skin under the influence of electroporation (Figure obtained from

The composition of the treatment cocktails used for Bio-revitalization largely depends on the skin problems to be treated (e.g., lines and wrinkles, skin sagging, sun damage or acne, etc.) and they are assembled prior to the treatment after the initial skin evaluation. Amongst Bioactive ingredients are a variety of human growth factor peptides, Hyaluronic acid, vitamins (A, C, E and B), extracts from different plants, etc. When delivered into the deeper layer of the skin, biostimulators will initiate synthesis of new collagen and other important components of the skin matrix like fibronectin, elastin, and hyaluronic acid and thus promote regeneration and rejuvenation of the skin. Bio-revitalization stimulates skin’s natural mechanisms of healing, repairing and regeneration and the visible results that will be obtained after each treatment session include:

  • Firmer skin, improved volume, lifted jawline and better facial contour

  • Refined skin texture

  • Reduction in the depth of fine lines and wrinkles

  • Hydrated and glowing skin

  • Reduced hyperpigmentation and more even skin tone

  • Healed sun damage 

  • Reduction in breakouts and healing of acne scaring


Bio-revitalization in a form of a Needle- free mesotherapy via electroporation is a trauma free and non-invasive procedureand it can be performed once every 2 to 4 weeks. There is no visible down-time (healing time) and no pain. The results obtained after each session are cumulative and a significant improvement in skin condition and rejuvenation will be more prominent over time, after several treatments. Regular skin care with a Needle-free Mesotherapy helps to unwind the clock naturally and allows you to look more like a younger and better version of yourself for a longer time, naturally and without any risk of skin damage - the so called “time freeze effect and a natural look”.


To enhance the effect of a Needle-free Mesotherapy it is combined with a prior superficial chemical peel or microdermabrasion treatment. Clients will see an immediate improvement in skin hydration, firmness, volume, facial contouring, and an overall look of the skin and an even greater improvement will be noticeable 2-4 weeks later when the formation of a new skin matrix (new collagen, elastin, hyaluronic acid etc.) has taken place.

Needle – free Mesotherapy via electroporation is performed using special instruments that allow for the delivery of the treatment cocktails of choice to the deeper layers of the skin without piercing the skin, painlessly and with no recovery time (no downtime). 


Areas that can be treated include: face, body (neck, décolleté, hands, knees, arms, stomach etc.) and scalp (to treat thinning hair),


Skin conditions treated include: 


  • aging skin with fine to moderate lines and wrinkles

  • saggy skin and volume loss

  • enlarged pores and poor skin texture

  • dry and sensitive skin

  • sun damaged skin

  • acne and acne scarring

  • eczema

  • hyper pigmentation (melasma, uneven skin tone) 




  • Needle-free Mesotherapy as a non-invasive type of Bio-revitalization treatment may be suitable for clients from 17 years of age to over 80 years.


  • It is IDEAL for MALE clients since there is no down-time (i.e., no signs of visible healing on the skin after the treatment) and there is no risk of permanently removing the facial hair like with IPL or laser treatments.

  • It is safe for ALL ETHNIC SKIN TYPES. Since the Needle-free Mesotherapy doesn’t cause skin piercing or any other trauma it is one of the safest forms of therapy for darker skins in which trauma-based treatments may cause PIH (Post-Inflammatory Hyperpigmentation).

  • It’s a great treatment for younger clients in their late 20s or early 30s to prevent aging and accumulation of sun damage and preserve their younger looking skin for decades ahead.

  • Since there is no mechanical or thermal trauma to the skin it is also ideal for clients of a more advanced age when a skin’s natural healing and regenerating response to trauma-based treatments (i.e., laser, microneedling, RF – Radio Frequency etc) is inefficient. In case of a trauma-free Mesotherapy, there is no need to rely solely on the aged skin’s ability to heal since the treatment cocktails with bioactive ingredients will already be providing all the building blocks and stimulation that’s needed at the older age to rejuvenate the skin.

  • Needle-free Mesotherapy is pain free and down-time free.

  • It is affordable and can be used on the face and body (neck, chest, hands, etc.).

  • It is safe to use on sensitive skins that have never been treated before; it is safe and efficient for treating the sensitive and aged skin around the eyes.

  • It produces immediate visible results and a long-term gradual improvement that lasts. 

  • Bio-revitalization provides multiple benefits for the skin: rejuvenation, hydration, anti-inflammatory, reduction in hyper pigmentation, reversal of sun damage.

Before & After

Before Treatment
After The First
Needle-free Mesotherapy

(The treatment is ideal for the rejuvenation of the delicate skin around the eyes. There is a noticable improvement in volume and smoother skin around the eyes. )  

Dr. Natela Rekhviashvili, NovaCeuticals

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